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うつ病の原因と腸内細菌 A cause of depression and intestinal bacteria

うつ病の原因として、これまでに神経伝達物質の異常、ストレス反応における内分泌学的異常、慢性炎症などの生物学的な要因が提唱されてきましたが、いまだに不明な部分が多いのが現状です。 ヒトの腸内には100兆個、重さにして約1~1.5kg、1000種類以上もの腸内細菌が生息し、食物からの栄養素の吸収、ビタミンやタンパク質の合成、体外からの新たな病原菌の侵入の防止など、多岐にわたる重要な機能を担っています。近年、腸内細菌は脳の機能にも影響を与えること(腸―脳相関)を示唆する研究結果が次々に報告されており、うつ病の発症要因として注目されるようになってきました。
うつ病の動物モデルを用いた検討では、うつ病様の行動異常やストレス反応において腸内細菌の関与を示唆する報告が増え、ビフィズス菌や乳酸菌といったいわゆる善玉菌はストレス反応を和らげる可能性が示唆されています。
As a cause of depression, biological factors such as neurotransmitter abnormality, endocrinologic abnormality in stress response, chronic inflammation, etc. have been proposed so far, but there are still many unknown parts currently . There are 100 trillion in the human intestine, about 1 to 1.5 kg in weight, more than 1000 kinds of intestinal bacteria live, absorption of nutrients from food, synthesis of vitamins and proteins, new pathogenic bacteria from outside the body We are taking various important functions such as prevention of invasion. In recent years, research results suggesting that intestinal bacteria affect brain functions (intestinal-brain correlation) have been reported one after another, and it has been drawing attention as a cause of depression.
In a study using an animal model of depression, reports suggesting the involvement of intestinal bacteria in depression-like behavior abnormalities and stress reactions increased, so-called good bacteria such as bifidus bacteria and lactic acid bacteria suggested the possibility of relieving the stress reaction It has been.

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